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Selenium exerts antioxidant activity on its own and enhances the benefits of other antioxidants. Selenium also acts as an antagonist to heavy metals such as mercury, aluminum, cadmium and lead. Selenium's major role is its incorporation in four active sites on the enzyme Glutathione Peroxidase. Glutathione Peroxidase is one of the major antioxidants protecting the body from free radical damage. Selenium is also involved in thyroid hormone production.